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Location where to get the Complete Article --> Ambient Science: Vol 3, No 2 (2016): 16-21

ISSN- 2348-5191 (Print version); 2348-8980 (Online)

Traditionally used Medicinal Plants in the Treatment of Kidney Stone: a Review on Ethnobotanical Studies in Iran

Mahmoud Mirhoseini, Mohammad Taghi Moradi, Majid Asadi-Samani


Urinary tract stone are considered as the third leading disease of the urinary tract, which is still increasing in prevalence mainly due to ever-changing dietary and lifestyle. Kidney stone removal treatments never give a guarantee against the recurrence of stone and the employed technique may lead to certain side effects. It is thus, necessary to develop a medical prophylactic program to prevent stone recurrence. This review is to identify and report the plants that are used for prevention and treatment of kidney stone in traditional culture from various regions of Iran. We found 56 plants which belong to the 23 floral families are in use as traditional medicine, to specifically treat kidney stone in Iran. Most of the reported plants were from Asteraceae and Rosaceae families with respective 12 and 6 species. Though most of the plants evaluated in this study contain phenolic compounds, their effects in treating nephrolithiasis may be explained antioxidant activities. div>


  • Akanae, W., Tsujihata, M., Yoshioka, I., Nonomura, N. & Okuyama, A. (2010): Orthosiphon grandiflorum has a protective effect in a calcium oxalate stone forming rat model. Urol. Res., 38: 89-96.
  • Amidi, N., Moradkhani, S., Sedaghat, M., Khiripour, N., Larki-Harchegani, A., Zadkhosh, N., Mirhoseini, M. & Ranjbar, A. (2016): Effect of green tea on inflammation and oxidative stress in cisplatin-induced experimental liver function. J. Herbmed Pharmacol., 5: 99-102.
  • Amiri, M.S. & Joharchi, M.R. (2013): Ethnobotanical investigation of traditional medicinal plants commercialized in the markets of Mashhad, Iran. Avicenna J. Phytomed., 3: 254-271.
  • Asadi-Samani, M., Kooti, W., Aslani, E. & Shirzad, H. (2016): A Systematic Review of Iran's Medicinal Plants With Anticancer Effects. J. Evid. Based Complementary Altern. Med., 21: 143-153.
  • Azizi, H. & Keshavarzi, M. (2015): Ethnobotanical study of medicinal plants of Sardasht, Western Azerbaijan, Iran. J. Herb. Drugs, 6: 113-119.
  • Bahmani, M., Shirzad, H., Rafieian, S. & Rafieian-Kopaei, M. (2015): Silybum marianum: Beyond Hepatoprotection. J. Evid. Based Complementary Altern. Med., 20: 292-301.
  • Bahmani, M., Tajeddini, P., Ezatpour, B., Rafieian-Kopaei, M., Naghdi, N. & Asadi-Samani, M. (2016): Ethenobothanical study of medicinal plants against parasites detected in Shiraz, southern part of Iran. Der Pharm. Let., 8: 153-160.
  • Baradaran, A., Rabiei, Z., Rafieian, M. & Shirzad, H. (2012): A review study on medicinal plants affecting amnesia through cholinergic system. J. Herbmed Pharmacol., 1: 3-9.
  • Cao, Z.G., Liu, J.H., Zhou, S.W., Wu, W., Yin, C.P. & Wu, J.Z. (2004): The effects of the active constituents of Alisma orientalis on renal stone formation and bikunin expression in rat urolithiasis model. Zhonghua Yi Xue Za Zhi, 84: 1276-1279.
  • Dolatkhahi, M., Dolatkhahi, A. & Nejad, J.B. (2014): Ethnobotanical study of medicinal plants used in Arjan - Parishan protected area in Fars Province of Iran. Avicenna J. Phytomed., 4: 402-412.
  • Dolatkhahi, M. & Nabipour, I. (2014): Ethnobotanical Study of Medicinal Plants Used in the Northeast Latrine Zone of Persian Gulf. J.Med. Plants, 2: 129-143.
  • Esmaeili, S., Malekmohammadi, M., Hassanpour, A. & Mosaddegh, M. (2014): Ethnobotanical survey of medicinal plants used traditionally in two villages of Hamedan, Iran. Res. J. Pharmacogn., 1: 7-14.
  • Ghorbani, A. (2005): Studies on pharmaceutical ethnobotany in the region of Turkmen Sahra, north of Iran: (Part 1): General results. J. Ethnopharmacol., 102: 58-68.
  • Jeong, B.C., Kim, B.S., Kim, J.I. & Kim, H.H. (2006): Effects of green tea on urinary stone formation: an in vivo and in vitro study. J. Endourol., 20: 356-361.
  • Jivad, N., Asadi-Samani, M. & Moradi, M.T. (2016a): The most important medicinal plants effective on migraine: A review of ethnobotanical studies in Iran. Der Phar. Chem., 8: 462-466.
  • Jivad, N., Bahmani, M. & Asadi-Samani, M. (2016b): A review of the most important medicinal plants effective on wound healing on ethnobotany evidence of Iran. Der Pharm. Let., 8: 353-357.
  • Karimi, A. & Moradi, M.T. (2015): Total phenolic compounds and in vitro antioxidant potential of crude methanol extract and the correspond fractions of Quercus brantii L. acorn. J. Herbmed Pharmacol., 4: 35-39.
  • Khan, S.R. & Thamilselvan, S. (2000): Nephrolithiasis: a consequence of renal epithelial cell exposure to oxalate and calcium oxalate crystals. Mol. Urol., 4: 305-312.
  • Kooti, W., Moradi, M., Ali-Akbari, S., Sharafi-Ahvazi, N., Asadi-Samani, M. & Ashtary-Larky, D. (2015): Therapeutic and pharmacological potential of Foeniculum vulgare Mill: a review. J. Herbmed Pharmacol., 4: 1-9.
  • Maymand, M.Z. & Mirtajodin, M. (2010): The collection and identification of the some plant species of Kerman province. J.Herb. Drug., 1: 1-24.
  • Mardaninejad, S., Janghorban, M. & Vazirpour, M. (2013): Collection and identification of medicinal plants used by the indigenous people of Mobarakeh (Isfahan), Southwestern Iran. J.Herb. Drugs, 4: 23-32.
  • Miraldi, E., Ferri, S. & Mostaghimi, V. (2001): Botanical drugs and preparations in the traditional medicine of West Azerbaijan (Iran). J. Ethnopharmacol., 75: 77-87.
  • Mirdeilami, S.Z., Barani, H., Mazandarani, M. & Heshmati, G.A. (2011): Ethnopharmacological survey of medicinal plants in Maraveh Tappe region, north of Iran. Iran. J.Plant Physiol., 2: 325-336.
  • Moradi, M.T., Rafieian-Kopaei, M. & Karimi, A. (2016a): A review study on the effect of Iranian herbal medicines against in vitro replication of herpes simplex virus. Avicenna J. Phytomed., 6: 506-515.
  • Moradi, M.T., Karimi, A., Alidadi, S. & Gholami-Arjenaki, M. (2015): In vitro anti-herpes simplex type-1 activity, antioxidant potential and total phenolic compounds of pomegranate (Punica granatum L.) peel extract. J.Chem. Pharm. Res., 7: 82-88.
  • Moradi, M.T., Gatreh-Samani, K., Farrokhi, E., Rafieian-Koupaei, M. & Karimi, A. (2012): The effects of purslane (Portulaca oleracea L.) on serum level of lipids, lipoproteins and paraoxanase 1(PON1) activity in hypercholesterolemia patients. Life Sci. J., 9: 5548-5552.
  • Moradi, M.T., Karimi, A. & Alidadi, S. (2016b): In vitro antiproliferative and apoptosis-inducing activities of crude ethyle alcohole extract of Quercus brantii L. acorn and subsequent fractions. Chin. J.Nat. Med., 14: 196-202.
  • Moradi, M.T., Karimi, A., Alidadi, S., Ghasemi-Dehkordi, P. & Ghaffari-Goosheh, M.S. (2016c): Cytotoxicity and in vitro antioxidant potential of Quercus Brantii acorn extract and the corresponding fractions. Int.J.Pharmacogn. Phytochem.Res., 8: 558-562.
  • Moradi, M.T., Rafieian-Koupaei, M., Imani-Rastabi, R., Nasiri, J., Shahrani M., Rabiei Z. & Alibabaei Z. (2013a): Antispasmodic effects of yarrow (Achillea millefolium L.) extract in the isolated ileum of rat. Afr. J. Tradit. Complement Altern. Med., 10: 499-503.
  • Moradi, M.T., Rafieian-Koupaei, M. & Shahrani, M. (2013b): The effect of garlic methanol extract on gastric acid and pepsin in basic and stimulated conditions by electrical stimulus of vagus nerve in rats. Life Sci. J., 10: 99-104.
  • Mosaddegh, M., Naghibi, F., Moazzeni, H., Pirani, A. & Esmaeili, S.(2012): Ethnobotanical survey of herbal remedies traditionally used in Kohghiluyeh va Boyer Ahmad province of Iran. J. Ethnopharmacol., 141: 80-95.
  • Nasri, H., Baradaran, A., Ardalan, M.R., Mardani, S., Momeni, A. & Rafieian-Kopaei, M. (2013): Bright renoprotective properties of metformin: Beyond blood glucose regulatory effects. Iran. J. Kidney Dis., 7: 423-428.
  • Nijveldt, R.J., Van Nood, E., Van Hoorn, D.E., Boelens, P.G., Van Norren, K. & Van Leeuwen, P.A. (2001): Flavonoids: a review of probable mechanisms of action and potential applications. Am. J. Clin. Nut., 74: 418-425.
  • Park, H.K., Jeong, B.C., Sung, M.K., Park, M.Y., Choi, E.Y., Kim, B.S., Kim, H.H. & Kim, J.I. (2008): Reduction of oxidative stress in cultured renal tubular cells and preventive effects on renal stone formation by the bioflavonoid quercetin. J. Urol., 179: 1620-1626.
  • Parsaei, P., Bahmani, M., Karimi, M., Naghdi, N., Asadi-Samani, M. & Rafieian-Kopaei, M. (2016a): A review of analgesic medicinal plants in Iran. Der Pharm. Let., 8: 43-51.
  • Parsaei, P., Bahmani, M., Naghdi, N., Asadi-Samani, M., Rafieian-Kopaei, M., Tajeddini, P. & Sepehri-Boroujeni, M. (2016b): Identification of medicinal plants effective on common cold: An ethnobotanical study of Shiraz, South Iran. Der Pharm. Let., 8: 90-97.
  • Premgamone, A., Sriboonlue, P., Disatapornjaroen, W., Maskasem, S., Sinsupan, N. & Apinives, C. (2001): A long-term study on the efficacy of a herbal plant, Orthosiphon grandiflorus, and sodium potassium citrate in renal calculi treatment. Southeast Asian J. Trop. Med. Public Health, 32: 654-660.
  • Rajaei, P. & Mohamadi, N. (2012): Ethnobotanical Study of Medicinal Plants of Hezar Mountain Allocated in South East of Iran. Iran. J. Pharm. Res., 11: 1153-1167.
  • Rouhi-Boroujeni, H., Asadi-Samani, M. & Moradi, M.T. (2016): A review of the medicinal plants effective on headache based on the ethnobotanical documents of Iran. Der Pharm. Let., 8: 37-42.
  • Safa, O., Soltanipoor, M.A., Rastegar, S., Kazemi, M., Dehkordi N.K. & Ghannadi, A. (2013): An ethnobotanical survey on hormozgan province, Iran. Avicenna J. Phytomed., 3: 64-81.
  • Samarghandian, S., Asadi-Samani, M., Farkhondeh, T., Bahmani, M. (2016): Assessment the effect of saffron ethanolic extract (Crocus sativus L.) on oxidative damages in aged male rat liver. Der Pharm. Let., 8: 283-90.
  • Mahmoudian Sani, M.R., Asadi-Samani, M., Rouhi-Boroujeni, H. & Banitalebi-Dehkordi, M. (2016): Phytopharmacology and phytotherapy of regulatory T cells: A new approach to treat multiple sclerosis. Der Pharm. Let., 8: 215-220.
  • Shahrani, M., Rafieian, M., Shirzad, H., Hashemzadeh, M., Yousefi, H., Khadivi, R., Amini, S.A., Dehghan, M., Khayri, S., Moradi, M., Rahimian, G. & Gheitasi, I. (2007): Effect of Allium sativum L. extract on acid and pepsin secretion in basal condition and stimulated with vag stimulate in rat. J. Med.Plants, 6: 28-37.
  • Touhami, M., Laroubi, A., Elhabazi, K., Loubna, F., Zrara, I., Eljahiri, Y., Oussama, A., Grases, F. & Chait, A. (2007): Lemon juice has protective activity in a rat urolithiasis model. BMC Urol., 7: 18.
  • Yuvanc, E., Yilmaz, E., Tuglu, D. & Batislam, E. (2015): Medical and alternative therapies in urinary tract stone disease. World J. Nephrol., 4: 492-499.

  • DOI:10.21276/ambi.2016.03.2.rv03/h3>

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